Diastereomeric discrimination capabilities of serine proteases.
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Diastereomeric discrimination capabilities of serine proteases. by Pierre R.* Bonneau

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Published .
Written in English


Book details:

The Physical Object
Pagination237 leaves
Number of Pages237
ID Numbers
Open LibraryOL20826217M

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Introduction. The serine protease inhibitor family is one of the most widely distributed natural proteinase inhibitors. Serine protease inhibitors are able to regulate certain proteases participated in many human physiological and pathological processes, such as peptide hormone release, digestion, host defence, blood coagulation, disease progression, hypertension, muscular dystrophy, cancer Cited by: 2. A selection of recent achievements in the development of peptidyl diaryl phosphonate inhibitors of serine proteases. Peptidyl di (p -chlorophenyl) phosphonates enabled selective inhibition of human neutrophil proteinase 3, thus, its differentiation from the structural homolog, neutrophil : Marta Maślanka, Artur Mucha. Characterization of the Human Cytomegalovirus Protease As an Induced-Fit Serine Protease and the Implications to the Design of Mechanism-Based Inhibitors Modulation of Lifetimes and Diastereomeric Discrimination in Triplet-Excited Substituted Butane-1,4-diones through Intramolecular Charge-Transfer Quenching Journal of the American. One of the oldest of the physical separation methods with a history of practical exploitation is the use of diastereomeric complexes for (partial) resolution of enantiomeric mixtures (Pasteur, ). The traditional method takes advantage of the differential solubility of Cited by: 1.

Owing to the bulkiness of the CDR kinetic discrimination in the course of derivatization has to be taken into account as well as the lowered volatility of the diastereomers . This led to a series of diastereomeric mixtures (18a–f) of highly potent inhibitors of tryptase with excellent selectivity against related serine proteases including trypsin as shown in Table 2. The diastereomeric mixture 18a was comparable to the guanidinylpropyl analogue Scheme 1, Scheme 2 in potency versus tryptase but exceedingly more selective against plasmin, uPA, and by: Regulation of serine protease activity by an engineered metal switch. Biochemistry. Sep 18; 29 (37)– Horrevoets AJ, Tans G, Smilde AE, van Zonneveld AJ, Pannekoek H. Thrombin-variable region 1 (VR1). Evidence for the dominant contribution of VR1 of serine proteases to their interaction with plasminogen activator inhibitor by: Serine protease inhibitors to treat inflammation: a patent review (). Expert Opinion on Therapeutic Patents , 28 (2), DOI: / Kai Chen, Chuan-De Wu. Designed fabrication of biomimetic metal–organic frameworks for catalytic by:

Action of endogenous proteases on texture deterioration of the bay scallop (Argopecten irradians) adductor muscle during cold storage and its mechanism. Action of endogenous proteases on texture deterioration of the bay scallop . Argopecten irradians.) adductor muscle during cold . Silanediol peptidomimetics have been prepared, designed to inhibit the serine protease enzyme Factor XIa (FXIa) for treatment of thrombosis without complete interruption of normal hemostasis.   This book aims to develop the theory of the discrimination process and relate this theory to certain features of the perceptual and cognitive development of the child. Organized into 21 chapters, this volume starts with a discussion of discrimination process whereby an organism responds to differences between Edition: 1.   (). Diastereomeric discrimination by achiral substances: the effect of diverse ions in the stability of amphi-ionophore cystine-based cyclopeptide stereoisomers. Molecular Physics: Vol. , No. 5, pp. Cited by: 1.